Journal
CELL REPORTS
Volume 30, Issue 11, Pages 3851-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.02.082
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Bo & Kerstin Hjelt Foundation
- Gertrude von Meissner Foundation
- European Commission (Marie Curie Career Integration Grant) [320898]
- European Commission (European Research Council [ERC] Proof of Concept Grant) [899766]
- European Commission (ERC) [614847]
- Geneva Cancer League
- Swiss Cancer League [KLS-3794-02-2016-R]
- Juvenile Diabetes Research Foundation [2-SRA-2019-846-S-B]
- LouisJeantet Foundation
- Fondation Pour Recherches Medicales of the University of Geneva
- Swiss National Science Foundation [310030_169966, 310030_184767, 310030_146533, 31003A_172999, PP00P3_163929]
- DiaGen2010
- La Fondation pour la Recherche sur le Diabete
- Swiss National Science Foundation (SNF) [310030_146533, 31003A_172999, PP00P3_163929, 310030_169966, 310030_184767] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [899766, 614847] Funding Source: European Research Council (ERC)
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Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (PPlase) FK506-binding protein 10 (FKBP10)-positive cells are present in cancer lesions but absent in the healthy parenchyma of human lung. FKBP10 expression negatively correlates with survival of lung cancer patients, and its downregulation causes a dramatic diminution of lung tumor burden in mice. Mechanistically, our results from gain- and loss-of-function assays show that FKBP10 boosts cancer growth and stemness via its PPlase activity. Also, FKBP10 interacts with ribosomes, and its downregulation leads to reduction of translation elongation at the beginning of open reading frames (ORFs), particularly upon insertion of proline residues. Thus, our data unveil FKBP10 as a cancer-selective molecule with a key role in translational reprogramming, stem-like traits, and growth of lung cancer.
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