Journal
CELL REPORTS
Volume 30, Issue 11, Pages 3729-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.02.095
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Funding
- Natural Sciences and Engineering Research Council, Canada [05069-2014]
- Canadian Institutes of Health Research, Canada [PT-74038]
- Canadian Foundation for Innovation, Canada [32477]
- McGill's Healthy Brains for Healthy Lives CFREF, Canada
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The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when reward is and is not available. Although direct pathway stimulation is rewarding and indirect pathway stimulation aversive, the activity of both cell types is elevated during periods of behavioral suppression, and the inhibition of either cell-type selectively increases unproductive reward seeking. Amygdala and thalamic inputs are also necessary for behavioral suppression, even though they both support self-stimulation and innervate different NAc subregions. These data suggest that efficient reward seeking relies on complementary activity across NAc cell types and inputs rather than opponent processes between them.
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