Journal
CHEMMEDCHEM
Volume 11, Issue 21, Pages 2392-2397Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201600334
Keywords
cancer stem cells; glutathione; leukemia; natural products; xenograft models
Categories
Funding
- US National Cancer Institute [1R21A141039]
- NIH/NCRR [RR025761]
Ask authors/readers for more resources
Recent studies suggest that leukemia stem cells (LSCs) play a critical role in the initiation, propagation, and relapse of leukemia. Herein we show that (-)-15-methylene-eburnamonine, a derivative of the alkaloid (-)-eburnamonine, is cytotoxic against acute and chronic lymphocytic leukemias (ALL and CLL) and acute myelogenous leukemia (AML). The agent also decreases primary LSC frequency invitro. The cytotoxic effects appear to be mediated via the oxidative stress pathways. Furthermore, we show that the compound kills AML, ALL, and CLL stem cells. By the use of a novel humanized bone marrow murine model of leukemia (huBM/NSG), it was found to decrease progenitor cell engraftment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available