Journal
TRAVEL MEDICINE AND INFECTIOUS DISEASE
Volume 35, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tmaid.2020.101646
Keywords
SARS-CoV-2; Coronavirus; Molecular docking; Approved drugs; Medications
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Background: The COVID-19 has now been declared a global pandemic by the World Health Organization. There is an emergent need to search for possible medications. Method: Utilization of the available sequence information, homology modeling, and in slico docking a number of available medications might prove to be effective in inhibiting the SARS-CoV-2 two main drug targets, the spike glycoprotein, and the 3CL protease. Results: Several compounds were determined from the in silico docking models that might prove to be effective inhibitors for SARS-CoV-2. Several antiviral medications: Zanamivir, Indinavir, Saquinavir, and Remdesivir show potential as and 3CL(PRO) main proteinase inhibitors and as a treatment for COVID-19. Conclusion: Zanamivir, Indinavir, Saquinavir, and Remdesivir are among the exciting hits on the 3CL(PRO) main proteinase. It is also exciting to uncover that Flavin Adenine Dinucleotide (FAD) Adeflavin, B2 deficiency medicine, and Coenzyme A, a coenzyme, may also be potentially used for the treatment of SARS-CoV-2 infections. The use of these off-label medications may be beneficial in the treatment of the COVID-19.
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