Journal
THORACIC CANCER
Volume 11, Issue 6, Pages 1369-1371Publisher
WILEY
DOI: 10.1111/1759-7714.13408
Keywords
BNIP3; cancer-associated fibroblasts; caveolin-1; E2F1; mitophagy
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Funding
- Science and Technology Project of the Health Planning Committee of Sichuan [19PJ242]
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In recent years, studies have found that E2F1, a downstream effector of caveolin-1 (Cav-1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1-MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradigm for regulation of the tumor cell metabolic reprogramming pathway by Cav-1 that is operationally linked and mutually dependent on the transcriptional activation of E2F1 and induces mitophagy with BNIP3 in cancer-associated fibroblasts (CAFs).
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