Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-020-65377-3
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Funding
- NIA [R21AG053740]
- NIMH [R01MH097082, R01MH085801, R21MH113177]
- American Foundation for Suicide Prevention (AFSP)
- Amon G. Carter Foundation
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The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120h after death, expanding the availability and use of human diseased tissue stored in brain banks.
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