Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-020-65110-0
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Funding
- Uppsala University Hospital, Uppsala University
- Foundation of Ingrid Lowenstrom, Tysta Skolan
- Swedish Deafness Foundation (HRF)
- Swedish Research Council [2017-03801]
- Tysta Skolan Foundation
- Swedish Hearing Research Foundation
- Canada Foundation for Innovation
- Natural Sciences and Engineering Research Council of Canada
- National Research Council Canada
- Canadian Institutes of Health Research
- Government of Saskatchewan
- Western Economic Diversification Canada
- University of Saskatchewan
- Uppsala University
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Meniere's disease remains enigmatic, and has no treatment with sufficient evidence. The characteristic histopathological finding is endolymphatic hydrops, suggesting either an overproduction or decreased reabsorption of endolymph in the human inner ear. This study presents the first analysis of the vascular plexus around the human endolymphatic duct using micro computed tomography and coherent synchrotron radiation with phase contrast imaging. Using a software program, data were processed by volume-rendering with scalar opacity mapping to create transparent three-dimensional reconstructions. A rich vascular plexus was discovered around the endolymphatic duct that drained into collecting channels, linked to the vestibular venous outflow system. This network is believed to make up the principal route for endolymph outflow, and its associated malfunction may result in endolymphatic hydrops and Meniere's disease.
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