Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-63802-1
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Funding
- Korean Health Technology RAMP
- D Project, Ministry of Health and Welfare, Republic of Korea [HI17C1799, HI19C0655]
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Little clinical evidence supports the strict implementation of glycemic control for diabetic patients with AMI. We aimed to demonstrate the effect of long-term glycemic control on mortality in patients with diabetes mellitus after acute myocardial infarction (AMI). Eight hundred and twenty-four consecutive diabetic patients were divided into three groups according to the mean hemoglobin (HbA1c) value: <6% (group A), >= 6% to <7.5% (group B), and >= 7.5% (group C). The best long-term mortality outcome was observed in Group B, followed by groups C and A. Groups B and C were further compared in-depth because the baseline characteristics of group A differed significantly. A Cox regression analysis indicated that Group C was associated with an adjusted hazard ratio (HR) of 1.55 [95% confidence interval (CI): 1.02-2.34, P=0.038]. An inverse probability of treatment weight analysis was performed to compare groups B and C. Group C had significantly higher mortality, compared to group B (adjusted HR: 1.58; 95% CI: 1.21-2.06, P<0.001). In conclusion, Glycemic status was associated with the long-term survival outcome in diabetic patients after AMI. However, further study is needed to prove whether HbA1c-targeted glycemic control can effectively improve survival after AMI.
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