Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 11, Issue 15, Pages 2139-2143Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201600669
Keywords
amphiphiles; chelates; contrast agents; gadolinium; liposomes
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Funding
- Compagnia di San Paolo (CSP, NANOPROGLY Project)
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Two amphiphilic mono- and dimeric GdAAZTA-like chelates composed of stable bis-aquo Gd-III complexes (q=2) linked to one (for the monomer) or two dodecyl aliphatic chains (for the dimer) were synthesized. Both chelates showed high relaxivity when incorporated into the lipid bilayer of liposomes or after interaction with human serum albumin (HSA). The ditopic complex shows a significantly decreased internal motion relative to the monomeric complex, associated with an enhanced relaxivity (r(1)approximate to 60mm(-1)s(-1), at 30MHz and 310K). The presence of two metal-bound water molecules in fast exchange and the restricted rotational freedom make the relaxivity of this system the highest measured for paramagnetic liposomes.
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