Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 17, Pages 5894-5898Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600234
Keywords
amides; amines; boronic acid; synthetic methods; transamidation
Categories
Funding
- ANR NeoACAT [ANR-JC-12]
- Labex SynOrg [ANR-11-LABX-0029]
- region Normandie
Ask authors/readers for more resources
A highly efficient and mild transamidation of amides with amines co-catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral alpha-amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron-derived Lewis acidity rather than an improved Bronsted acidity of acetic acid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available