Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 20, Pages 6759-6763Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601101
Keywords
annulation; C-H activation; cobalt; density functional calculations; isoquinolones; oxidase
Categories
Funding
- European Research Council under the European Community [307535]
- DFG [SPP 1807]
- Chinese Scholarship Program
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Cp*-free cobalt-catalyzed alkyne annulations by C-H/N-H functionalizations were accomplished with molecular O-2 as the sole oxidant. The user-friendly oxidase strategy proved viable with various internal and terminal alkynes through kinetically relevant C-H cobaltation, providing among others step-economical access to the anticancer topoisomerase-I inhibitor 21,22-dimethoxyrosettacin. DFT calculations suggest that electronic effects control the regioselectivity of the alkyne insertion step.
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