Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 47, Pages 16804-16807Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604344
Keywords
8-aminoquinoline; C-H activation; cleavage; directing group; ozonolysis
Categories
Funding
- graduate program MolTag (Austrian Science Fund FWF) [W1232]
- Fundacao para a Ciencia e Tecnologia [SFRH/BPD/100677/2014]
- ERASMUS program
Ask authors/readers for more resources
8-Aminoquinoline has emerged as one of the most powerful bidentate directing groups in history of C-H activation within the last decade. However, cleavage of its robust amide bond has shown to be challenging in several cases, thus jeopardizing the general synthetic utility of the method. To overcome this limitation, we herein report a simple oxidative deprotection protocol. This transformation rapidly converts the robust amide to a labile imide, allowing subsequent cleavage in a simple one-pot fashion to rapidly access carboxylic acids or amides as final products.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available