Journal
NUTRIENTS
Volume 12, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/nu12030794
Keywords
allophycocyanin; bioactive peptides; C-Phycocyanin; DPP-IV; LC-MS; MS; Spirulina platensis
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Funding
- Fondo di Sostegno della Ricerca - Linea 2 (University of Milan) - University of Milan
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Arthrospira platensis (spirulina) is a cyanobacterium, which contains mainly two phycobiliproteins (PBP), i.e., C-phycocyanin (C-PC) and allophycocyanin (APC). In this study, PBP were hydrolyzed using trypsin, and the composition of the hydrolysate was characterized by HPLC-ESI-MS/MS. Furthermore, the potential anti-diabetic activity was assessed by using either biochemical or cellular techniques. Findings suggest that PBP peptides inhibit DPP-IV activity in vitro with a dose-response trend and an IC50 value falling in the range between 0.5 and 1.0 mg/mL. A lower inhibition of the DPP-IV activity expressed by Caco-2 cells was observed, which was explained by a secondary metabolic degradation exerted by the same cells.
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