Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 20, Pages 6964-6967Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600333
Keywords
green chemistry; hydroxamic acids; photochemistry; organocatalysis; vorinostat
Categories
Funding
- Latsis Foundation
Ask authors/readers for more resources
An efficient one-pot synthesis of hydroxamic acids from aldehydes and hydroxylamine is described. A fast, visible-light-mediated metal-free hydroacylation of dialkyl azodicarboxylates was used to develop the subsequent addition of hydroxylamine hydrochloride. A range of aliphatic and aromatic aldehydes were employed in this reaction to give hydroxamic acids in high to excellent yields. Application of the current methodology was demonstrated in the synthesis of the anticancer medicine vorinostat.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available