Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 42, Pages 14806-14811Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601714
Keywords
biodegradable; bridged silsesquioxanes; drug delivery; enzymes; nanoparticles
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Funding
- King Abdullah University of Science and Technology
- University of California, Los Angeles
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We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
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