Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 43, Pages 15216-15221Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603294
Keywords
cancer chemotherapy; mannose-mediated targeting; multivalency; nanoparticles; targeted drug delivery
Categories
Funding
- National Natural Science Foundation of China [51403081]
- Natural Science Foundation of Jiangsu Province [BK20140137]
- Fundamental Research Funds for the Central Universities [JUSRP51629B]
- Max Planck Society International Partner Group Program
- High-end Foreign Experts Recruitment Program
- Thousand Talents Plan (Young Professionals)
- China Scholarship Council
- Max-Planck Society
Ask authors/readers for more resources
Multivalent mannose-functionalized nanoparticles self-assembled from amphiphilic beta-cyclodextrins (beta-CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin ( DOX)-loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor-mediated endocytosis by MDA-MB-231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available