Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 12, Pages 3952-3955Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201505214
Keywords
alcohols; allylic compounds; amination; hydrogen borrowing; iron
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Funding
- Indian Institute of Technology Kanpur [IITK/CHM/20130187]
- DAE-BRNS [BRNS/CHM/2014110]
- IITK
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Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one-step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.
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