4.6 Article

Electrochemical Oxidative C-H/N-H Coupling between γ-Lactams and Anilines

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 40, Pages 14293-14296

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602454

Keywords

C-H/N-H coupling; electrochemistry; metal free; gamma-lactams; anilines

Funding

  1. National Natural Science Foundation of China [21172080, 21372089]

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A mild method for the direct C-H/N-H coupling between gamma-lactams and anilines through electrochemical oxidation has been developed. The protocol proceeded smoothly without metal catalysts at room temperature to afford gamma-substituted gamma-lactams in good yields. It has been revealed that the quasi-divided cell which provided high current density on the anode was crucial for this reaction.

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