Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 1, Pages 176-186Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604579
Keywords
Fenton reagent; flow chemistry; Minisci reaction; radical reactions; trifluoromethylation
Categories
Funding
- Brazilian Science without Borders program (CNPq, CAPES)
- FAPESP [2014/21319-8]
- CNPq [200566/2014-8/PDE]
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We report an operationally simple and rapid continuous flow radical C-C bond formation under Minisci-type reaction conditions. The transformations are performed at or below room temperature employing hydrogen peroxide (H2O2) and dimethylsulfoxide (DMSO) as reagents in the presence of an Fe-II catalyst. For electron-rich aromatic and heteroaromatic substrates, C-C bond formation proceeds satisfactorily with electrophilic radicals including (CF3)-C-center dot, (C4F9)-C-center dot, (CH2CN)-C-center dot, and (CH2CO2Et)-C-center dot. In contrast, electron-poor substrates exhibit minimal reactivity. Importantly, trifluoromethylations and nonafluororobutylations using CF3I and C4F9I as reagents proceed exceedingly fast with high conversion for selected substrates in residence times of a few seconds. The attractive features of the present process are the low cost of the reagents and the extraordinarily high reaction rates. The direct application of the protocol to dihydroergotamine, a complex ergot alkaloid, yielded the corresponding trifluoromethyl ergoline derivative within 12 seconds in a continuous flow microreactor on a 0.6 kg scale. The trifluoromethyl derivative of dihydroergotamine is a promising therapeutic agent for the treatment of migraines.
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