Journal
ACS CATALYSIS
Volume 10, Issue 11, Pages 6457-6462Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c01436
Keywords
allylation; C-H activation; cobalt; electrocatalysis; selectivity; unactivated alkenes
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Funding
- DFG (Gottfried-Wilhelm-Leibniz award)
- DAAD
- CSC
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Versatile and robust cobalt catalysis enabled the electrochemical C-H allylation with nonactivated alkenes. In contrast to precious palladium, rhodium, iridium, and ruthenium catalysts that are limited to electronically activated styrenes and acrylates, we herein disclose cobalt-catalyzed electro-oxidative C-H allylations with nonactivated alkenes. Thus, allylated benzamides were obtained with high levels of chemoselectivity, positional selectivity, and regioselectivity in the biomass-derived solvent gamma-valerolactone. Detailed mechanistic studies provided strong support for a base-assisted internal electrophilic-type substitution mechanism for the key C-H activation step. The cobaltaelectro-catalysis overall achieved resource-economy by avoiding the use of stoichiometric chemical oxidants, with H-2 as the only byproduct.
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