Journal
ACS CATALYSIS
Volume 10, Issue 11, Pages 6058-6070Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c01519
Keywords
beta-functionalization; alpha,beta-desaturation; carbonyl compound; conjugate addition; migratory coupling; redox cascade
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Funding
- University of Chicago
- NSF [CHE1855556]
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Capitalizing on versatile catalytic a, beta-desaturation methods, strategies that directly functionalize carbonyl compounds at their less-reactive beta-positions have emerged over the past decade. Depending on the reaction mechanism, general approaches include merging with conjugate addition, migratory coupling, and redox cascade. This perspective provides a summary of transition-metal-catalyzed alpha,beta-desaturation methods and in-depth discussions of each beta-functionalization strategy with their advantages, challenges, and future directions.
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