Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 49, Pages 17715-17724Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602809
Keywords
drug delivery; iron; liposomes; magnetic properties; nanoparticles
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Funding
- SNF Sinergia grant [CRSII2 154451]
- Ministry of Science and Higher Education, Diamond Grant [DI2013 017243]
- European Union from the European Regional Development Fund
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Studies on magnetoliposomes (MLUV) as potential carriers for magnetic-field-dependent drug delivery are presented. The systems were formed with hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) confined within the bilayer of the liposomes. The nanomechanical properties of bilayer lipid membranes were evaluated and related to the amount of incorporated SPIONs. It was found that the presence of SPIONs in the lipid membrane leads to overall stiffening and increases morphological inhomogeneity, facilitating rupture of the MLUV membrane in a low-frequency alternating magnetic field (AMF). To verify the findings, doxorubicin release from MLUVs in the presence and absence of an AMF was measured. Under experimental conditions, drug release proceeds through MLUV rupture induced by mechanical vibration of SPIONs rather than through localized heating in the vicinity of the SPIONs.
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