Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-16337-y
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Funding
- Secretaria d'Universitats i Recerca del Departament d'Economia iCreixement, Generalitat de Catalunya [2017FI_B1_00202, 2017FI_B2_00029]
- Plan Estrategico (PERIS) of the Generalitat de Catalunya
- Ministerio de Economia y Competitividad [FPI BES-2017081657]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [793830]
- NIH [RO1A124710, RO1AI0555994]
- PE I+D+i 2013-2016 from the Instituto de Salud Carlos III (ISCIII) [PT17/0019]
- ERDF
- Spanish Ministry of Science, Innovation and Universities, Centro de Excelencia Severo Ochoa 2013-2017 [SEV-2012-0208]
- Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya [2017SGR595]
- Fundacion Ramon Areces
- Ministerio Espanol de Economia y Competitividad [SAF2016-80655-R]
- Fundacion Ramon Areces, 2014, Investigacion en Ciencias de la Vida y de la Materia, Project Exosomas: Nuevos comunicadores intercelulares y su aplicabilidad como agentes terapeuticos en enfermedades parasitarias desatendidas
- Marie Curie Actions (MSCA) [793830] Funding Source: Marie Curie Actions (MSCA)
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Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.
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