Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-15593-2
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Funding
- Institut National de la Sante et de la Recherche Medicale [ATIP-Avenir program (2012-2016)]
- Rgion Midi-Pyrenees Excellence program (2013-2016)
- Scientifiques de la Fondation ARC [PJA 20171206526, PJA20191209714]
- French government through the UCAJEDI Investments in the Future project [ANR-15-IDEX-01]
- Investments for the Future LABEX SIGNALIFE [ANR-11-LABX-0028-01]
- Tramplin ERC program from the National Research Agency [ANR-16-TERC-0018-01]
- ATIP-Avenir program from the CNRS
- Human Frontier Science Program [CDA00027/2017-C]
- National Institutes of Health [GM-R35GM122596, GM46425]
- Agence Nationale de la Recherche (ANR) [ANR-16-TERC-0018] Funding Source: Agence Nationale de la Recherche (ANR)
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Actomyosin supracellular networks emerge during development and tissue repair. These cytoskeletal structures are able to generate large scale forces that can extensively remodel epithelia driving tissue buckling, closure and extension. How supracellular networks emerge, are controlled and mechanically work still remain elusive. During Drosophila oogenesis, the egg chamber elongates along the anterior-posterior axis. Here we show that a dorsal-ventral polarized supracellular F-actin network, running around the egg chamber on the basal side of follicle cells, emerges from polarized intercellular filopodia that radiate from basal stress fibers and extend penetrating neighboring cell cortexes. Filopodia can be mechanosensitive and function as cell-cell anchoring sites. The small GTPase Cdc42 governs the formation and distribution of intercellular filopodia and stress fibers in follicle cells. Finally, our study shows that a Cdc42-dependent supracellular cytoskeletal network provides a scaffold integrating local oscillatory actomyosin contractions at the tissue scale to drive global polarized forces and tissue elongation. During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.
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