Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-15487-3
Keywords
-
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81771983, 81971771, 81750410695, 81750110544, 81650110523, 81851110764, 61425006]
- Shanghai Science and Technology Commission [16441909300]
- Ministry of Science and Technology of China [YS2017YFGH002082, 2017YFC0909000]
- Shanghai Rising-Star Program [19QA1404800]
- Clinical Research Plan of SHDC [16CR2011A]
- Shanghai Municipal Health Commission [2019CXJQ03]
Ask authors/readers for more resources
Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 mu L of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available