Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 15, Pages 5409-5415Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201504845
Keywords
alkaloids; amines; aminonitriles; photocatalysis; total synthesis
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A highly efficient metal-free catalytic system for the aerobic photocyanation of tertiary amines with visible light is reported. The use of air as terminal oxidant offers an improved safety profile compared with pure oxygen, the used compact fluorescent lamp (CFL) light sources are highly economical, and no halogenated solvents are required. This system not only proves to be effective for a wide variety of trialkylamines, pharmaceuticals, and alkaloids but remarkably also allows the lowest catalyst loading (0.00001mol% or 0.1ppm) ever reported for an organic dye. Bruylants reactions and C-alkylation/decyanations were performed on the obtained -aminonitriles to demonstrate the postfunctionalization of complex molecules. The catalytic system is furthermore applied in the short and effective syntheses of the alkaloids (+/-)-crispineA and the tetraponerines T7 and T8.
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