Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-15371-0
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Funding
- HFSP [LT000110/2015-L/1]
- Spanish Ministerio de Ciencia e Innovacion (MCI) [SAF2015-64287R, SAF2017-90604-REDT-NurCaMein, RTI2018-095928-B100]
- La Marato de TV3 Foundation [201605-32]
- Comunidad de Madrid [MOIR-B2017/BMD-3684]
- Formacion de Profesorado Universitario programme (MCI) [FPU17/01731]
- MCI
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
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Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility and the transcriptional regulation of canonical macrophage genes. RXR deficiency impairs neonatal expansion of the LPM pool and reduces the survival of adult LPMs through excess lipid accumulation. We also find that peritoneal LPMs infiltrate early ovarian tumours and that RXR deletion diminishes LPM accumulation in tumours and strongly reduces ovarian tumour progression in mice. Our study reveals that RXR signalling controls the maintenance of the serous macrophage pool and that targeting peritoneal LPMs may improve ovarian cancer outcomes.
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