Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41467-020-15095-1
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LR17F050001]
- National Science Foundation of China [21788102, 21805002, 61735016, 61975172]
- Research Grants Council of Hong Kong [AHKUST605/16, C6009-17G]
- Innovation and Technology Commission [ITCCNERC14SC01, ITCPD/17-9]
- Science and Technology Plan of Shenzhen [JCYJ20180507183832744]
- Ming Wai Lau Centre for Reparative Medicine Associate Member Programme
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Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500-1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.
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