Journal
EPIGENOMICS
Volume 12, Issue 6, Pages 487-505Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0173
Keywords
ceRNA; epithelial-mesenchymal transition; HNSCC; KTN1-AS1; lncRNA miR; -153-3p
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Funding
- National Natural Science Foundation of China [81874126, 81972573, 81772933, 81472515]
- 64th Post-doctoral Science Foundation of China [2018M642049]
- Shanghai Science and Technology Commission [18JC1413700, 18DZ2291500]
- Oral and Maxillofacial Surgery Academician Workstation of Zhengzhou [152PYSGZ040]
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Aim: To explore the biological functions and clinicopathologic significance of the long noncoding RNA KTN1-AS1 in head and neck squamous cell carcinoma (HNSCC). Materials & methods: We assessed the effects of KTN1-AS1 and identified the target miRNA by bioinformatics analysis, luciferase reporter, RNA pull-down and RNA immunoprecipitation assays. The clinicopathologic features of KTN1-AS1 and its target miRNA were analyzed in HNSCC. Results: KTN1-AS1, a competing endogenous RNA, promoted cell proliferation, migration, invasion and epithelial-mesenchymal transition by sponging miR-153-3p in HNSCC. Dysregulation of SNAI1 and ZEB2 mediated the effect of KTN1-AS1 due to miR-153-3p exhaustion. The KTN1-AS1 and miR-153-3p combination can accurately diagnose HNSCC. Conclusion: The KTN1-AS1 and miR-153-3p combination could be a valuable diagnostic and prognostic predictor for HNSCC.
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