Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 34, Pages 12006-12010Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602953
Keywords
ESIPT; flow chemistry; heterocycles; photocycloaddition; rocaglate
Categories
Funding
- National Institutes of Health [GM-073855, R01A175744]
- Canadian Institutes for Health Research [MOP-115126]
- NSF
- [R24M111625]
Ask authors/readers for more resources
Synthesis of aza-rocaglates, nitrogen-containing analogues of the rocaglate natural products, is reported. The route features ESIPT-mediated (3+2) photocycloaddition of 1-alkyl-2-aryl-3-hydroxyquinolinones with the dipolarophile methyl cinnamate. A continuous photoflow reactor was utilized for photocycloadditions. An array of compounds bearing the hexahydrocyclopenta[b]indole core structure was synthesized and evaluated in translation inhibition assays.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available