Journal
ONCOTARGETS AND THERAPY
Volume 13, Issue -, Pages 2747-2755Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S231010
Keywords
colorectal cancer; mechanical environment; matrix stiffness; signaling pathway; colon fibroblasts; drug resistance
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Funding
- Nature Scientific Foundation of China [81702956]
- Strategy-Oriented Special Project of Central South University in China [ZLXD2017003]
- XiangYa-Peking University Wei Ming Clinical and Rehabilitation Research Fund [xywm2015I21]
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In recent years, a growing consensus is emerging that the mechanical micro-environment of tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis. Matrix stiffness, one of the sources of mechanical stimulation, affects tumor cells as well as non-tumor cells in multiple different molecular signaling pathways in solid tumors such as colorectal tumors, which lead to tumor invasion and metastasis, immune evasion and drug resistance. This review will illustrate the relationship between matrix stiffness and colorectal cancer from the following aspects. First, briefly introduce the mechanical microenvironment and colorectal cancer, then explain the origin of colorectal cancer extracellular matrix stiffness, and then synthesize the study of matrix stiffness of colorectal cancer in recent years to elaborate the effects of extracellular matrix stiffness in colorectal cancer's biological behavior and signaling pathways, and finally we will discuss the transformation treatment for the matrix stiffness of colorectal cancer. An in-depth understanding of matrix stiffness and colorectal cancer can help researchers conduct further experiments to find new targets for the treatment of colorectal cancer.
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