Journal
JOURNAL OF CHEMICAL RESEARCH
Volume 44, Issue 9-10, Pages 576-579Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1747519820911849
Keywords
(E)-2-aroyl-4-(4-fluorobenzylidene)-5-oxopyrrolidines; HeLa; proliferation; synthesis; Ugi 4CC; S-N
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Funding
- National Natural Science Foundation of China [81872509]
- Hubei Provincial Technology Innovation Project [2017ACA176]
- Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine) [WDCM2018001]
- Shiyan Municipal Science and Technology Bureau Science and technology project [18K79, 18Y01]
- scientific research innovation team of Hubei University of Medicine [2014QDJZR10, 2014CXZ01]
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Seven (E)-2-aroyl-4-(4-fluorobenzylidene)-5-oxopyrrolidines were synthesized via a tandem Ugi 4CC/S(N)cyclization sequence starting from a Baylis-Hillman-derived acid, primary amines, arylglyoxals, and isocyanides in one pot. In addition, the cytotoxicity of these compounds on the cervical cancer cell line HeLa was studied by MTT assay. The results showed that most of the compounds could inhibit the proliferation of HeLa cells significantly.
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