Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 47, Pages 16764-16768Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603829
Keywords
alkynes; cycloaddition; nickel; nitriles; pyridines
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Funding
- National Natural Science Foundation of China [21125210, 21421091]
- Chinese Academy of Science
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A Ni/BPh3 catalyzed [2+2+2] cycloaddition of alkyne-nitriles with alkynes has been developed, which provides an efficient route to fused pyridines under mild reaction conditions. Mechanistic studies indicate that an azanickelacycle via heterocoupling of an alkyne with a nitrile moiety is possibly formed as a key reaction intermediate. The Lewis acid catalyst is crucial to the successful transformation, which is suggested to promote the oxidative cyclization process.
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