Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 22, Pages 7617-7622Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600849
Keywords
C-N bond formation; iodine; imidazo[1,2-a]pyridin-2-amine; oxidative cyclization; sequential synthesis
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Funding
- National Natural Science Foundation of China [81302637, 81330075]
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A novel and practical strategy for the construction of imidazo[1,2-a]pyridin-2-amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I-2/KI-mediated oxidative C-N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2-amino substituted imidazo[1,2-a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.
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