Journal
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
Volume 12, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/wnan.1638
Keywords
cancer; heat shock proteins; hyperthermia; immune response; thermal ablation
Funding
- National Science Foundation [NSF-CBET 1804416]
- NSF-CBET [1933321, NSF-MRI-1337438]
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [1933321] Funding Source: National Science Foundation
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Hyperthermia is a rapidly growing field in cancer therapy and many advances have been made in understanding and applying the mechanisms of hyperthermia. Secondary effects of hyperthermia have been increasingly recognized as important in therapeutic effects and multiple studies have started to elucidate their implications for treatment. Immune effects have especially been recognized as important in the efficacy of hyperthermia treatment of cancer. Both thermo-ablative and mild hyperthermia activate the immune system, but mild hyperthermia seems to be more effective at doing so. This may suggest that mild hyperthermia has some advantages over thermo-ablative hyperthermia and research into immune effects of mild hyperthermia should continue. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery
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