Formation of C(sp3)-C(sp3) Bonds through Nickel-Catalyzed Decarboxylative Olefin Hydroalkylation Reactions

Olefins and carboxylic acids are among the most important feedstock compounds. They are commonly found in natural products and drug molecules. We report a new reaction of nickel-catalyzed decarboxylative olefin hydroalkylation, which provides a novel practical strategy for the construction of C(sp(3))-C(sp(3)) bonds. This reaction can tolerate a variety of synthetically relevant functional groups and shows good chemo-and regioselectivity. It enables cross-coupling of complex organic molecules containing olefin groups and carboxylic acid groups in a convergent fashion.