Journal
TRENDS IN NEUROSCIENCES
Volume 43, Issue 7, Pages 505-518Publisher
CELL PRESS
DOI: 10.1016/j.tins.2020.05.002
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Funding
- National Institute of Neurological Disorders and Stroke Intramural Research Program
- National Institute of Mental Health [NS112480-01]
- Simons Foundation
- McKnight Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003140] Funding Source: NIH RePORTER
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Changes in the actin cytoskeleton are a primary mechanism mediating the morphological and functional plasticity that underlies learning and memory. The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have emerged as central regulators of actin dynamics at the synapse. The increased attention surrounding Kalirin and Trio stems from the growing evidence for their roles in the etiology of a wide range of neurodevelopmental and neurodegenerative disorders. In this Review, we discuss recent findings revealing the unique and diverse functions of these paralog proteins in neurodevelopment, excitatory synaptic transmission, and plasticity. We additionally survey the growing literature implicating these proteins in various neurological disorders.
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