Journal
TRENDS IN MOLECULAR MEDICINE
Volume 26, Issue 9, Pages 803-818Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2020.03.010
Keywords
-
Funding
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- King's College London Graduate School PGR (postgraduate research) International Research Studentship
- Medical Research Council (MRC) [MR/N030087/1, MR/S00484X/1]
- Royal Society Wolfson Research Merit Award
- Wolfson Foundation
- Royal Society
- MRC [MR/S00484X/1] Funding Source: UKRI
Ask authors/readers for more resources
Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available