Journal
TRENDS IN MOLECULAR MEDICINE
Volume 26, Issue 5, Pages 469-482Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2020.02.003
Keywords
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Funding
- National Key Research and Development Program of China [2017YFA0205200, 2016YFC0102600]
- National Natural Science Foundation of China (NSFC) [21877057, 81930053, 61622117]
- Beijing Nova Program [Z181100006218046]
- Jiangmen Program for Innovative Research Team [2018630100180019806]
- Department of Radiology, Stanford University
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Near-IR fluorescence imaging (NIRFI) is a highly promising technique for improving cancer theranostics in the era of precision medicine. Through the combination with cutting-edge bionanotechnologies, the potential of NIRFI can be greatly broadened. A variety of novel NIRF nanoprobes has been developed with ultimate goals of addressing unmet medical needs. Here, we present recent breakthroughs on the fundamental aspects of NIRFI, such as imaging at long wavelengths (1000-1700 nm), and the use of new approaches (X-rays, chemiluminescence, radioluminescence, etc.) for the excitation of novel nanoprobes. Within two decades, research on NIRF nanoprobes has translated to clinical trials and it will further translate to cancer management.
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