Journal
TRENDS IN MICROBIOLOGY
Volume 28, Issue 7, Pages 566-577Publisher
CELL PRESS
DOI: 10.1016/j.tim.2020.02.007
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Funding
- Leverhulme Trust, UK [RPG-2015-184]
- Innovate UK: SBRI [971621]
- Wellcome Trust Developing Concept Fund [RG93172]
- BBSRC [BB/F002912/1] Funding Source: UKRI
- Innovate UK [971621] Funding Source: UKRI
- MRC [1933099] Funding Source: UKRI
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Indole is a signalling molecule produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signalling. Despite the increasing volume of research published in this area, many aspects of indole signalling remain enigmatic. There is disagreement over the mechanism of indole import and export and no clearly defined target through which its effects are exerted. Progress is hindered further by the confused and sometimes contradictory body of indole research literature. We explore the reasons behind this lack of consistency and speculate whether the discovery of a new, pulse mode of indole signalling, together with a move away from the idea of a conventional protein target, might help to overcome these problems and enable the field to move forward.
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