Journal
TRENDS IN CELL BIOLOGY
Volume 30, Issue 8, Pages 653-667Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2020.04.006
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Funding
- Oncode Institute - Dutch Cancer Society
- KWF [11080]
- Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior [NORTE-01-0145-FEDER-030507, CEECIND/00333/2017]
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The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.
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