Journal
TRENDS IN BIOTECHNOLOGY
Volume 38, Issue 12, Pages 1360-1372Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.04.010
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Funding
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [7R01AI134911]
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Microfluidics has proven to be a powerful tool for probing biology at the single-cell level. However, it is only in the past 5 years that single-cell microfluidics has been used in the field of virology. An array of strategies based on microwells, microvalves, and droplets is now available for tracking viral infection dynamics, identifying cell subpopulations with particular phenotypes, as well as high-throughput screening. The insights into the virus-host interactions gained at the single-cell level are unprecedented and usually inaccessible by population-based experiments. Therefore, single-cell microfluidics, which opens new avenues for mechanism elucidation and development of antiviral therapeutics, would be a valuable tool for the study of viral pathogenesis.
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