Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 5, Pages 371-374Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2020.02.005
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Funding
- CPER Longevity
- French Ligue Contre le Cancer (Comite du Nord)
- French Ligue Contre le Cancer (Comite de la Somme)
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Senescence is a complex cellular state, which can be considered as a stress response phenotype. However, the mechanisms through which cells acquire and maintain this phenotype are not fully understood. In this paper, it is argued that the unfolded protein response (UPR) may represent a signalling platform that is associated with the major senescence hallmarks.
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