Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 4, Pages 963-969Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604787
Keywords
carbon dots; cell imaging; fluorescent probes; multicolour fluorescence imaging; nanostructures; photothermal therapy
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Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS2-C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS2 NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS2-C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles.
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