Journal
THYROID
Volume 30, Issue 11, Pages 1547-1555Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/thy.2019.0727
Keywords
Alzheimer's disease; subclinical hypothyroidism; amyloid-beta; thyroid hormone; thyrotropin
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Funding
- National Research Foundation of Korea (NRF) - Korea Government (MSIP) [2018R1C1B5047075, 2014R1A5A2010008, 2017R1C1B5017721]
- National Research Foundation of Korea [2017R1C1B5017721, 2018R1C1B5047075] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Background:Although several studies have reported an association between thyroid dysfunction and Alzheimer's disease (AD), the effect of mild thyroid dysfunction within the normal range of thyrotropin (TSH) on the development of AD remains unclear. The aim of this study was to evaluate the association between thyroid hormones and the pathology of AD in euthyroid subjects. Methods:Sixty-nine subjects with a TSH level between 0.5 and 4.5 mu IU/L who underwent(18)F-florbetaben positron emission tomography were included in this prospective cross-sectional study. The levels of serum free thyroxine (fT4) and TSH were quantified using radioimmunoassay. Neuropsychological tests were performed to assess cognitive function. Differences in cerebral amyloid-beta (A beta) burden were compared between high-normal TSH (TSH >= 2.5 mu IU/mL) and low-normal TSH (TSH <2.5 mu IU/mL) groups. Multiple linear regression analyses, adjusted for age, sex, education level, and Neuropsychiatric Inventory scores, were performed to evaluate relationships between thyroid hormone levels and both cerebral A beta burden and cognitive function. Results:The cerebral A beta burden in the high-normal TSH group was significantly higher than in the low-normal TSH group (1.53 +/- 0.31 vs. 1.35 +/- 0.22,p = 0.009). The fT4 levels were negatively correlated with cerebral A beta burden (beta = -0.240,p = 0.035), and TSH levels were positively correlated with cerebral A beta burden (beta = 0.267,p = 0.020). The fT4 level was also positively associated with cognitive function, as inferred from neuropsychological test scores. Conclusions:Thyroid hormone concentrations were associated with AD pathology in euthyroid subjects. Our findings suggest that AD is likely to occur even in individuals with high-normal TSH levels.
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