Journal
TALANTA
Volume 212, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2020.120795
Keywords
Ln-MOFs; Fluorescent sensing; Bio-marker; Clinical diagnosis
Categories
Funding
- National Natural Science Foundation of China [51472087]
- Shanghai Municipal Natural Science Foundation [19ZR1415400]
- Opening Project of Key Laboratory of Transparent Opto-functional Inorganic Materials,Chinese Academy of Sciences [KLTOIM201606]
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In the present study, a kind of Eu(III) post-functionalized Zr(IV)-based metal-organic framework (UiO-66(COOH)(2), Zr-MOF: Eu3+) was synthesized and utilized as an independently luminescent probe for sensing bilirubin (BR) in human serum, a biomarker of jaundice hepatitis. It can be served as a turn-off fluorescent switch for BR because its red emission from Eu3+ can be easily quenched by BR through a fluorescent resonant energy transfer (FRET) process between BR and its ligands, and as a result, BR is recognized successfully. Particularly, Zr-MOF: Eu3+ has shown many appealing properties, such as high sensitivity, quick response (less than 1 min), broad response window (0-15 mu M), and excellent selectivity. Most importantly, a kind of portable test paper based on Zr-MOF: Eu3+ probe has been developed for directly assessing the level of BR in real human serum and further diagnosing bilirubin-related diseases via visually observing the luminescent color variation.
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