Journal
TALANTA
Volume 210, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2019.120642
Keywords
Botryosphaeria rhodina MAMB-05; MWCNTs aqueous dispersion; Modified glassy carbon electrode; Pharmaceutical analysis; Biological sample
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Funding
- Brazilian funding agency CAPES [88882.448537/2019-01]
- Brazilian funding agency CNPq [408591/2018-8]
- Brazilian funding agency Fundacao Araucaria do Parana [001/17-3765]
- Brazilian funding agency Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [CEPID/CDMF 2013/07296-2]
- Brazilian funding agency CAPES (PROAP 2018)
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The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 mV s(-1), the developed sensor presented a sensitivity of 1.018 mu A L mu mol(-1) in the linear working range of 1.99-32.9 mu mol L-1, with a detection limit of 0.88 mu mol L-1 of DESL in 0.10 mol L-1 potassium hydrogen-phosphate solution (pH 8.0). In addition, the sensor showed excellent repeatability with a relative standard deviation of only 1.02% for a sequence of 10 measurements. The sensor was successfully applied in the analysis of pharmaceutical preparations containing DESL, with equivalent results compared to a validated spectrophotometric method at the 95% confidence level. The sensor was also employed in the analysis of a spiked sample of DESL in rat serum.
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