Journal
SYNTHETIC COMMUNICATIONS
Volume 50, Issue 14, Pages 2188-2198Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2020.1769673
Keywords
Green chemistry; quinoline; pyrimidines; thiazolidine; ultraviolet
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An efficient and facile approach for the synthesis of new quinoline derivatives was accomplished via reactions of 2-chloroquinoline-3-carbaldehyde with active methylene compounds, for example, 1,3-dimethylbarbituric acid, thiobarbituric acid and 2,4-dioxothiazolidine and aromatic amines through one-pot multi-component reaction (MCR) as sources of pyrimidine and thiazolidine derivatives bearing quinoline moiety. All compounds were synthesized via conventional and Microwave Irradiation conditions. The best results (short reaction times, pure products, high yield) were obtained by microwave irradiation. The synthesized derivatives were characterized by various physicochemical and spectral techniques from their analytical and spectral data.
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