Journal
STEM CELL RESEARCH
Volume 44, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2020.101758
Keywords
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Funding
- Swedish Research Council [2015-02424]
- Hjarnfonden [FO2019-0210]
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The role of Neurochondrin (NCDN) in humans is not well understood. Mice with a conditional Ncdn knock-out show epileptic seizures, depressive-like behaviours and impaired spatial learning. Using CRISPR/Cas9, we generated a Neurochondrin deficient human iPSC line KICRi002-A-3 carrying a homozygous 752 bp deletion / 2 bp insertion in the NCDN gene. The iPSC line maintained a normal 46,XY karyotype, expressed pluripotency markers and exhibited capability to differentiate into the three germ layers in vitro. Off-target editing was excluded and Neurochondrin expression was not detectable. The iPSC line offers a valuable resource to study the role of Neurochondrin during human neurogenesis.
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