Journal
SMALL
Volume 16, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202000809
Keywords
biodegradable nanocomposites; chemo-phototherapy; copper sulfide nanocomposites; deep tumor therapy; dual cell-tissue penetration
Categories
Funding
- National Natural Science Foundation of China [21822802, 51772018, 51572271, 51972343]
- National Basic Research Program of China [2016YFA0201500]
- Fundamental Research Funds for the Central Universities [XK1901, buctrc201915, XK1802-8]
- Research projects on biomedical trans-formation of ChinaJapan Friendship Hospital [PYBZ1825]
- Foundation of Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University [JDSJ2018-09]
- Fundamental Research Funds for the Central Universities
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Chemo-phototherapy, as a promising cancer combination therapy strategy, has attracted widespread attention. However, the complex tumor microenvironment restricts the penetration depth of chemo-phototherapy agents in the tumor region. Here, biodegradable amphiphilic gelatin (AG) wrapped nanocomposite (PRDCuS@AG) composed of doxorubicin and copper sulfide (CuS)-loaded dendrimer is designed for deep tumor chemo-phototherapy. PR in PRDCuS@AG represents arginine-conjugated polyamidoamine dendrimer. PRDCuS@AG can rapidly biodegrade into PRDCuS by matrix metalloproteinases under near-infrared light irradiation. The resulted PRDCuS harbors dual cell-tissue penetration ability, which can effectively penetrate deep into the tumor tissue. In particular, PRDCuS@AG achieves photoacoustic imaging-guided synergistic chemo-phototherapy with 97% of tumor inhibition rate. Moreover, PRDCuS@AG can further degrade into 3 nm ultrasmall CuS, which can be eliminated from the body after treatment to avoid side effects. This strategy provides an insight that the development of chemo-phototherapy agents with high penetration ability to overcome the limitation of current deep tumor therapy.
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